File Name: cancer and vitamin c linus pauling .zip
The selective anticancer properties of vitamin C are known since at least four decades. However, only recently in vitro studies have shown that vitamin C, in high enough concentrations, can efficiently and selectively kill a number of different human tumor cell lines, and these data have been confirmed in experimental animal tumor models. The first human clinical trials revealed that high doses of vitamin C administered by intravenous injection are not only very well tolerated but also substantially improve the quality of life of patients with clinically advanced cancer. However, the clinical evidence of the effectiveness of vitamin C in fighting off cancer is still controversial. The present chapter outlines the importance of vitamin C for a number of physiological functions, within the human body, and shows that there is a solid rationale for its use in the routine treatment of cancer, either alone or in combination with conventional treatment. Vitamin C.
I have, however, formulated the hypothesis which has not yet been tested by experiment that the effectiveness of ascorbic acid in providing protection against viral diseases results from its function in the synthesis and activity of interferon in preventing the entry of virus particles into the cells. The discovery of interferon was reported in by Isaacs and Lindenmann. It is a protein that is produced by cells infected by a virus and that has the property of spreading to neighboring cells and changing them in such a way as to enable them to resist infection. In this way the interferon ameliorates the disease. I estimate that for many people 1 g [gram] to 2 g per day mg to mg per day is approximately the optimum rate of ingestion. There is evidence that some people remain in very good health, including freedom from the common cold, year after year, through the ingestion of only mg of ascorbic acid per day. The requirements of a few people for ascorbic acid may be expected to be even smaller.
High doses of vitamin C, given every day, without ever stopping, to patients with cancer, as an adjunct to appropriate conventional therapy, improve the general health of nearly every cancer patient, increase survival time somewhat, and have great value for a fortunate few, who respond especially well. Most users should sign in with their email address. If you originally registered with a username please use that to sign in. To purchase short term access, please sign in to your Oxford Academic account above. Don't already have an Oxford Academic account? Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.
Show more about author. Vitamin C is an essential nutrient involved in many biological and biochemical processes as an antioxidant. As oxidative damage is implicated in the development of various diseases, vitamin C could have a preventive or even therapeutic effect. Fruits and vegetables are the recommended sources of vitamin C. Five servings of fruits and vegetables are protective against cancer and cardiovascular disease, however not because of vitamin C alone.
Contents Summary Function Role in immunity Bioavailability Deficiency The RDA Disease Prevention Cardiovascular disease Cancer Type 2 diabetes mellitus.
Vitamin C megadosage is a term describing the consumption or injection of vitamin C ascorbic acid in doses well beyond the current Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2, milligrams per day. Pauling argued that because humans lack a functional form of L-gulonolactone oxidase , an enzyme required to make vitamin C that is functional in most other mammals, plants, insects, and other life forms, humans have developed a number of adaptations to cope with the relative deficiency. These adaptations, he argued, ultimately shortened lifespan but could be reversed or mitigated by supplementing humans with the hypothetical amount of vitamin C that would have been produced in the body if the enzyme were working.
January 24, , by Lewis Cantley and Jihye Yun. Lewis Cantley received his Ph. Jihye Yun received her Ph. The discovery and isolation of vitamin C was one of the most important advances in improving human nutrition.
Vitamin C L-ascorbic acid is a potent reducing agent, meaning that it readily donates electrons to recipient molecules Figure 1. Vitamin C is the primary water-soluble, non-enzymatic antioxidant in plasma and tissues. Even in small amounts, vitamin C can protect indispensable molecules in the body, such as proteins , lipids fats , carbohydrates , and nucleic acids DNA and RNA , from damage by free radicals and reactive oxygen species ROS that are generated during normal metabolism , by active immune cells, and through exposure to toxins and pollutants e. Vitamin C also participates in redox recycling of other important antioxidants; for example, vitamin C is known to regenerate vitamin E from its oxidized form see the article on Vitamin E. The role of vitamin C as a cofactor is also related to its redox potential. By maintaining enzyme-bound metals in their reduced forms, vitamin C assists mixed-function oxidases in the synthesis of several critical biomolecules 1. These enzymes are either monooxygenases or dioxygenases see Table 1.
Vitamin C, Linus Pauling was right all along. A doctor's opinion Written by undefined on Invalid date. Summary It is the 10th anniversary of the death of Linus Pauling and his most controversial scientific conjectures about the health benefits of vitamin C are being confirmed. The weight of evidence may yet force the medical establishment to accept his ideas on nutrition and health.
Она подняла голову. - Не поддающийся взлому алгоритм? - Она выдержала паузу. - Ах да… Я, кажется, что-то такое читала. - Не очень правдоподобное заявление. - Согласна, - сказала Сьюзан, удивившись, почему вдруг Хейл заговорил об. - Я в это не верю. Всем известно, что невзламываемый алгоритм - математическая бессмыслица.
У нее свело желудок. - Останься со. В ее сознании замелькали страшные образы: светло-зеленые глаза Дэвида, закрывающиеся в последний раз; тело Грега Хейла, его сочащаяся кровь на ковре; обгорелый труп Фила Чатрукьяна на лопастях генератора. - Боль пройдет, - внушал Стратмор. - Ты полюбишь. Сьюзан не слышала ни единого слова. - Останься со мной, - увещевал ее голос.
Это была мелочь, но все же изъян, отсутствие чистоты - не этого она ожидала от Танкадо, наносящего свой коронный удар. - Тут что-то не так, - наконец сказала. - Не думаю, что это ключ. Фонтейн глубоко вздохнул. Его темные глаза выжидающе смотрели на Сьюзан. - Мисс Флетчер, как вы полагаете, если это не ключ, то почему Танкадо обязательно хотел его отдать.